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Delhiraj, N.
- Spectrophotometric Estimation of Ofloxacin in Pharmaceutical Dosage Form
Abstract Views :315 |
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, A.S.N Pharmacy College, Tenali, Andhra Pradesh
1 Department of Pharmaceutical Analysis, A.S.N Pharmacy College, Tenali, Andhra Pradesh
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 17-18Abstract
Simple, accurate and rapid Spectrophotometric method was developed for the estimation of ofloxacin in tablet dosage form. The method is based on the absorption of electromagnetic radiation by cefixime at the maximum wavelength at 294 nm in 0.1M Hydrochloric acid as solvent. Beer's law was obeyed in the concentration range of 10-80 μg/ml. The percentage assay for commercial formulation was found to be 100.02± 0.82.Recovery value was found to be 99.95±0.54.Keywords
Ofloxacin, Spectrophotometric Methods, Statistical Analysis, Recovery Studies
References
- Indian pharmacopeia, Volume III , Govt of India, Ministry of Health and Family Welfare, Published by the controller of publication, New Delhi. 2007, 146
- Senthilraja. M . Simultaneous UV spectrophotometric method for estimation of nitazoxanide and ofloxacin in combined dosage form. Ind. J. Pharm. Tech. 2008; 1:469-471.
- Wankhede, S.B., Prakash A., Chitlange S.S. Simultaneous spectrophotometric method for estimation of ofloxacin and satranidazole in tablet dosage from” Asian J. Research Chem. 2008;1:9-11
- Fegade, D., Mehta H. P., Chaudhari, R. Y., Patil V. R. Simultaneous spectrophotometric method for estimation of ofloxacin and ketorolac tromethamine in ophthalmic dosage forms. Int. J. Chem Tech Research. 2009; 1:189-194.
- Mathur SC., Kumar Y., Murgesan N., Rathode YK.S, Sethi PD. Spectrophotometric determination of ofloxacin in pharmaceutical formulation. Indian Drugs. 1992; 29: 376-377.
- Amini M,, Abdi K., Darabi M., Shafiee A. Determination of ofloxacin in plasma by HPLC with UV Detection. J. Appli, Sci. 2005; 5: 1655-1657
- Chandhra I., Hemanth Kumar AK. Simple and rapid High performance liquid chromatography methods for the determination of ofloxacin concentration in plasma and urine. J. Chromatogar. B 2001; 760: 91 -95
- Shinde S. R., Bhor S I., Pawar N. S.,Yadav S. B., Bhagawath A.M. . Simultaneous estimation of satranidazole and ofloxacin in tablet dosage form by high performance liquid chromatography. Journal of Chemistry. 2010; 7:198-202.
- Garcia MA, Solan C, Calvo A, Royo M, Hernandej C, Rey R, Bregante MA. Analysis of ofloxacin in plasma samples by high performance liquid chromatography. Chromatographia. 2002; 55; (7-8): 431-434.
- Dhandapani B, Thirumoorthi N, Rasheed SH, Kotaiah MH, Anjaneyalu N. Method development and validation for the simultaneous estimation of ofloxacin and orinidazole in tablet dosage form by RP-HPLC. International Journal on Pharmaceutical on Biomedical Research. 2010; 1(1):42-47.
- Gandhimathi M., Ravi T. K., Shukla N. Validated high performance thin layer chromatography method for simultaneous estimation of ofloxacin and ornidazole in tablet dosage form. Ind. J. Pharm. Sci. 2006; 68:838-840.
- Spectrophotometric Methods for the Determination of Racecadotril in Bulk and Pharmaceutical Dosage Forms
Abstract Views :189 |
PDF Views:0
Authors
Affiliations
1 Prist University, Vallam, Thanjavur, Tamil Nadu, IN
2 Department of Pharmaceutical Analysis, Nimra College of Pharmacy, Vjayawada, A.P, IN
3 Department of Pharmaceutical Analysis, K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada, A. P., IN
1 Prist University, Vallam, Thanjavur, Tamil Nadu, IN
2 Department of Pharmaceutical Analysis, Nimra College of Pharmacy, Vjayawada, A.P, IN
3 Department of Pharmaceutical Analysis, K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada, A. P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1739-1741Abstract
Two simple, sensitive and cost effective Spectrophotometric methods are developed for the determination of Racecadotril in bulk drug and pharmaceutical dosage forms. The methods are based on the oxidation of Racecadotril by ferric chloride in presence of Bathophenanthroline (Method A) and reduction of Folin ciocalteau reagent in the presence of sodium carbonate (Method B). The colored complex formed was measured at 603 and 742 nm for methods A and B respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer's law is valid within a concentration range of 20-120 μg/ml and 20-140 μg/ml for method A and B respectively. The mean percentage recoveries are 98.2 and 100.02 for method A and B respectively. The developed methods are applied for the determination of Racecadotril in bulk and its pharmaceutical formulations without any interference from excipients.Keywords
Spectrophotometry, Racecadotril.- Spectrophotometric Methods for the Determination of Racecadotril in Bulk and Pharmaceutical Dosage Forms
Abstract Views :190 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Analysis, Brown’s College of Pharmacy, Khammam, A.P, IN
2 Department of Pharmaceutical Analysis, K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada, A.P, IN
1 Department of Pharmaceutical Analysis, Brown’s College of Pharmacy, Khammam, A.P, IN
2 Department of Pharmaceutical Analysis, K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada, A.P, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 548-550Abstract
Three simple, sensitive and cost effective Spectrophotometric methods are developed for the determination of Racecadotril in bulk drug and pharmaceutical dosage forms. These methods are based on the oxidation of Racecadotril by ferric chloride in presence of 1, 10-phenanthroline (Method A) or 2, 2'bipyridyl (Method B) or potassium ferricyanide (Method C). The colored complex formed was measured at 510, 520 and 720 nm for methods A, B and C respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer’s law is valid within a concentration range of 25-100 μg/ml, 20-120μg/ml and 200- 1200 μg/ml for method A, B and C respectively. The mean percentage recoveries are 99.82, 100.1, 99.86 for method A, B and C respectively. The developed methods are applied for the determination of Racecadotril in bulk and its pharmaceutical formulations without any interference from excipients.